A. Scarpa

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct expression patterns and potential markers of progression

This study profiles proteins and glycoproteins in pancreatic neoplasms to identify expression patterns and potential progression markers.

The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in Pancreatic Ductal Adenocarcinoma

This study identifies EIF4A3 as an oncogenic factor in PDAC by showing its overexpression correlates with poor prognosis and its role in regulating RNA splicing and tumor growth.

Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

This study identifies MAPK signalling as defining fibroblast subtypes in pancreatic cancer, linking MAPKhigh CAFs to poor prognosis and immune evasion.

Spoink, a LTR retrotransposon, invaded D. melanogaster populations in the 1990s

The paper identifies Spoink, a LTR retrotransposon that invaded D. melanogaster populations between 1983 and 1993, likely via horizontal transfer from D. willistoni, and shows it is often silenced by the piRNA pathway.

ecDNA amplification of MYC drives intratumor copy-number heterogeneity and adaptation to stress in PDAC

Genomes of historical specimens reveal multiple invasions of LTR retrotransposons in Drosophila melanogaster populations during the 19th century.

This study identifies three LTR retrotransposon invasions in Drosophila melanogaster during the 19th century, adding to previous 20th-century invasions and providing a 200-year timeline of transposable element spread.

The impact of paramutations on the invasion dynamics of transposable elements

This study uses simulations to show paramutations accelerate TE silencing, reduce insertions, and mitigate fitness costs, addressing three open issues with the trap model.

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

This study shows SEMA3A promotes aggressive basal-like PDAC by enhancing metastasis and modulating the tumor microenvironment through macrophage polarization and T cell exclusion.

Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer

This study identifies adaptive DNA methylation changes and clonal expansion as mechanisms of resistance to MEKi in PDAC, showing reversibility upon drug withdrawal.

MAP Kinase inhibition reshapes tumor microenvironment of mouse pancreatic cancer by depleting anti-inflammatory macrophages

This study shows that MEK inhibition in mouse pancreatic cancer reduces anti-inflammatory macrophages and enhances gemcitabine efficacy by altering the tumor microenvironment.

ARF5/MONOPTEROS directly regulates miR390 expression in theArabidopsis thaliana primary root meristem