Orchestration of differential mesodermal fate choice from ESCs by Wnt-USP3 link and H2A/H2B contextual deubiquitination.
The paper identifies USP3 as a Wnt-regulated histone deubiquitinase that modulates mesodermal fate choices by altering H2A/H2B ubiquitination, promoting hemangioblasts over cardiomyocytes.
bioRxiv · Jul 1, 2023 · PreprintCell Biology