Syndecan-4-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components
S. B. Roenning, C. Carlson, J. M. Aronsen, A. Pisconti, V. Hoest, M. Lunde, K. H. Liland, I. Sjaastad, S.-O. Kolset, M. E. Pedersen
This study investigates the effects of syndecan-4 genetic ablation on muscle development and ECM remodeling in mice, finding smaller muscle fibers and altered pathway activations.
bioRxiv · Jun 10, 2020Cell Biology