Potent activation of NAD+-dependent deacetylase Sirt7 by nucleosome binding
V. I. Kuznetsov, W. Liu, M. Klein, J. Denu
This study identifies nucleosome binding as a key activator of Sirt7 deacetylase activity, revealing its efficiency and limitations in chromatin context.
bioRxiv · May 11, 2022Biochemistry