M. Klein

Drosophila larvae demonstrate associative learning and memory in response to thermal conditioning

This study shows Drosophila larvae can form short-term associative memories by linking temperatures with appetitive or aversive stimuli through thermal conditioning.

Coenzyme A biosynthesis in Bacillus subtilis: Discovery of a novel precursor metabolite for salvage and its uptake system

This study identifies a novel salvage pathway for coenzyme A in Bacillus subtilis, involving the uptake of cysteinopantetheine via a cystine transporter.

Transcriptomics and trans-organellar complementation reveal a limited signaling capacity of 12-cis-oxo-phytodienoic acid in wounded Arabidopsis

The paper investigates OPDA signaling in Arabidopsis by comparing transcriptomes of mutants and applying OPDA externally, finding limited signaling capacity and compartmentalization of endogenous OPDA.

Low exposure to lithium does not induce nephrogenic diabetes insipidus but microcystic dilations of collecting ducts in a long-term rat model

This study shows that low lithium exposure in rats causes microcystic dilations of collecting ducts without inducing nephrogenic diabetes insipidus.

PCSK9 inhibition protects mice from food allergy

This study shows that PCSK9 inhibition protects mice from gliadin-induced food allergy symptoms, independent of LDLR.

Unveiling IRF4-steered regulation of context-dependent effector programs in Th17 and Treg cells

This study identifies IRF4 interactors and their role in regulating context-dependent transcriptional programs in Th17 and Treg cells using ChIP-Seq and proteomics.

Continuous, long-term crawling behavior characterized by a robotic transport system

The paper introduces a robotic system for long-term continuous observation of Drosophila larval behavior, revealing bimodal navigation efficiency and similar dynamics in short- and long-term experiments.

Potent activation of NAD+-dependent deacetylase Sirt7 by nucleosome binding

This study identifies nucleosome binding as a key activator of Sirt7 deacetylase activity, revealing its efficiency and limitations in chromatin context.

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.

Mechanical vibration patterns elicit behavioral transitions and habituation in crawling Drosophila larvae

This study examines how Drosophila larvae respond to repeated mechanical vibrations, identifying behavioral transitions and habituation patterns.

Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium

This study examines SFD patient-derived iPSC-RPE for extracellular matrix dysfunction and oxidative stress, finding increased sub-RPE deposits and elevated 4-hydroxyproline levels.

Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids

This study determines the atomic structure of PLEKHA7's PH domain and reveals its multivalent interaction mechanism with membrane-bound PIPs, providing insights for inhibitor design.

Wild flies hedge their thermal preference bets in response to seasonal fluctuations

The paper tests if thermal preference variation in Drosophila melanogaster reflects a bet-hedging strategy across regions and finds evidence supporting this evolutionary strategy.

Skipping and sliding to optimize target search on protein-bound DNA and RNA

The paper shows that skipping and sliding motions allow searchers to maintain search speed on crowded nucleic-acid substrates, as demonstrated by analyzing human and bacterial Argonaute proteins.

A mechanistic model improves off-target predictions and reveals the physical basis of SpCas9 fidelity

This paper develops a mechanistic model to predict SpCas9 off-target activity and explains its structural basis for fidelity.

Argonaute bypasses cellular obstacles without hindrance during target search

This study shows Argonaute proteins efficiently search for targets by gliding over secondary structures and bypassing protein barriers through lateral diffusion and intersegmental jumps.

Dengue virus infection changes Aedes aegypti oviposition olfactory preferences

This study shows that dengue virus infection in Aedes aegypti mosquitoes reduces their preference for skatole-based oviposition sites, suggesting altered olfactory behavior.