Methyl substituted β-lactam framework based antibiotics and β-lactamase inhibitors: Proof of concept by computations
V. Thakkur, C. K. Das, S. Verma, S. Saha, N. N. Nair
This paper presents a computational proof of concept for methyl-substituted β-lactam antibiotics that slow deacylation of the acyl-enzyme complex by 109-fold without affecting binding to β-lactamase.
bioRxiv · Jan 14, 2024 · PreprintBiochemistry