S. Verma

Genome-wide association studies in a diverse strawberry collection unveil loci controlling agronomic and fruit quality traits

This study identifies 121 marker-trait associations across 95 QTLs for 26 agronomic and fruit quality traits in strawberries, with a major QTL on chromosome 6A linked to fruit firmness via the FaPG1 gene.

A Machine Learning-based approach for Simultaneous Electrochemical Detection of Interfering Analytes

This paper develops a machine learning approach to improve the accuracy of simultaneous electrochemical detection of interfering analytes by reducing prediction error.

Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis.

This study identifies ZAG/AZGP1 as a secreted factor from triple-negative breast cancer cells that promotes fibrosis in the tumor microenvironment and is linked to poor patient prognosis.

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells

This study shows CD55 supports MZ B cell survival and regulates TLR9 signaling, with loss of CD55 leading to reduced survival and increased apoptosis in aged mice.

Methyl substituted β-lactam framework based antibiotics and β-lactamase inhibitors: Proof of concept by computations

This paper presents a computational proof of concept for methyl-substituted β-lactam antibiotics that slow deacylation of the acyl-enzyme complex by 109-fold without affecting binding to β-lactamase.

A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.

SARS-CoV-2 infection leads to sustained testicular injury and functional impairments in K18 hACE2 mice

This study investigates the long-term effects of SARS-CoV-2 infection on testicular injury and function in K18-hACE2 mice, showing sustained damage and recovery within 4 weeks.

Antigen-level resolution of commensal-specific B cell responses enabled by phage-display screening and B cell tetramers

This study identifies SFB-specific B cell responses using phage display and tetramers, revealing compartmentalized activation and isotype gradients in the gut.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

This study shows that pre-existing mechanical tension at adherens junctions impairs apoptotic extrusion in epithelia, and this effect can be reversed by reducing tension.

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resistance

The paper shows that caveola disassembly under mechanical stress reinforces the actin cortex at adherens junctions, enhancing epithelial resistance to tensile stress.

Desmosome-anchored intermediate filaments facilitate tension-sensitive RhoA signaling for epithelial homeostasis

The paper identifies a mechanism where desmosome-anchored intermediate filaments enable RhoA signaling at adherens junctions to maintain epithelial homeostasis under tension.

Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia.

The paper shows that apical extrusion prevents apoptosis from triggering inflammation in epithelia by eliminating apoptotic cells before they activate an IL-8-driven inflammatory response.

In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.

This study shows SARS-CoV-2 does not directly infect human testicular cells but causes injury through bystander effects from systemic inflammation or viral antigens.

Live visualization of endoplasmic reticulum redox potential in zebrafish embryos reveals region-specific differences

This study uses transgenic zebrafish to visualize ER redox potential in live embryos, revealing region-specific deviations from expected oxidizing states.

Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function

This study identifies melanoma addiction to GCDH, showing that GCDH controls NRF2 glutarylation, which limits apoptotic UPR signaling and tumor growth.

Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health

This paper designs and in silico validates two multi-epitope vaccines against Nipah virus, incorporating CTL and HTL epitopes, B cell epitopes, and adjuvants, with potential for effective and specific immune response.

The nuclear effector ArPEC25 from the necrotrophic fungus Ascochyta rabiei targets the chickpea transcription factor CaβLIM1a and negatively modulates lignin biosynthesis for host susceptibility

The Ascochyta rabiei effector ArPEC25 enters the host nucleus and targets the transcription factor CaβLIM1a to manipulate phenylpropanoid pathway for negative modulation of chickpea lignin biosynthesis.

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

This study shows that loss of full-length dystrophin in myoblasts causes cell-autonomous defects in gene expression, proliferation, chemotaxis, and differentiation, contributing to muscle regeneration failure in Duchenne muscular dystrophy.

Enhanced RhoA signaling stabilizes E-cadherin in migrating epithelial monolayers.

The paper shows that RhoA signaling at adherens junctions stabilizes E-cadherin during epithelial migration by increasing junctional contractility and mechanical tension.

ST6GAL1-mediated heterogeneity in sialic acid levels potentiates invasion of breast cancer epithelia

This study identifies 2,6-linked sialic acid heterogeneity in breast cancer cells and shows that medium-expressing cells exhibit greater ECM adhesion and invasion compared to high-expressing cells, with ST6GAL1 playing a key role.

Genetic Analysis of Methyl Anthranilate, Mesifurane, Linalool and Other Flavor Compounds in Cultivated Strawberry (Fragaria xananassa)

This study identifies QTL and candidate genes for flavor compounds in strawberry using multi-omics analyses, revealing novel genes and pathways involved in volatile compound biosynthesis.

Computationally validated SARS-CoV-2 CTL and HTL Multi-Patch Vaccines designed by reverse epitomics approach, shows potential to cover large ethnically distributed human population worldwide

This paper designs and validates Multi-Patch Vaccines against SARS-CoV-2 using a reverse epitomics approach, showing potential to cover a large ethnically diverse human population.

A unified view of neighbour cell engagement during apoptotic cell extrusion.

This study identifies RhoA activation via a Myosin VI-dependent mechanotransduction pathway as the mechanism by which apoptotic cells engage neighboring cells for extrusion, with S1P providing priming.

Transplantation of muscle stem cell mitochondria rejuvenates the bioenergetic function of dystrophic muscle

This study shows that transplanting healthy muscle stem cells into dystrophic muscle improves mitochondrial function and bioenergetics, while compromised stem cells fail to do so.

LC/MS-QToF Profiling, Anti-Diabetic and Anti-Adipogenic potential of Divya MadhuKalp: A Novel Herbo-mineral Formulation

This study evaluates the anti-diabetic and anti-adipogenic effects of the herbo-mineral formulation Divya MadhuKalp using in vitro and in vivo models.

Regulation of HDAC2-PDX1 by RNF125 defines pancreatic cancer development

This study identifies RNF125's role in regulating HDAC2 and PDX1 to influence pancreatic cancer development and patient outcomes.

Single molecule tracking reveals the role of transitory dynamics of nucleoid-associated protein HU in organizing the bacterial chromosome

This study uses single molecule tracking to show HU binds and unbinds DNA weakly and transiently in E. coli, suggesting a dynamic role in chromosome organization.

Caveolae set levels of epithelial monolayer tension to eliminate tumor cells

The paper shows caveolae regulate epithelial tension through lipid signaling, enabling the elimination of oncogene-transformed cells by apical extrusion.

Snail induces epithelial cell extrusion through transcriptional control of RhoA contractile signalling and cell matrix adhesion

This study shows Snail induces cell extrusion through RhoA contractile signaling and reduced basal adhesion, independent of EMT.