Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition
T. Isermann, K. L. Schneider, F. Wegwitz, T. De Oliveira, L.-C. Conradi, V. Volk, F. Feuerhake, B. Papke, S. Stintzing, B. Mundt, F. Kuehnel, U. M. Moll, R. Schulz-Heddergott
This study shows that combining HSP90 inhibitors with p53 activation or CDK4/6 inhibition enhances colorectal cancer therapy by disrupting the HSF1-HSR feedback loop.
bioRxiv · Feb 22, 2024Cancer Biology