Vadim Vasilyev

A robust negative association between estimated tumour circadian clock function and survival in early stage breast cancer

The paper assesses the relationship between tumour circadian clock function and survival in breast cancer patients using a machine-learning model called TimeTeller, finding a negative association between clock function and survival.

Cationic antimicrobial copolymers reveal immunomodulatory properties in LPS stimulated macrophages in vitro

This study investigates the immunomodulatory effects of cationic antimicrobial copolymers on LPS-stimulated macrophages, finding anti-inflammatory and antimicrobial properties in specific copolymers.

Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

This study identifies ZFHX3's role in regulating circadian gene expression in the SCN by mapping its genomic binding sites and analyzing transcriptomic changes in ZFHX3 mutants.

Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts

This study tests RRx-001 in mouse endometriosis models, showing lesion regression and pain reduction without fertility impact.

TimeTeller: a tool to probe the circadian clock as a multigene dynamical system

TimeTeller estimates circadian clock function from single transcriptomes by modeling the multi-dimensional state of the clock, demonstrating its application across species and data types.