Chromatin Remodelling in Damaged Intestinal Crypts Orchestrates Redundant TGFβ and Hippo Signalling to Drive Regeneration
Mardi Fink, Kizito Njah, Shyam J. Patel, David P. Cook, Vanessa Man, Francesco Ruso, Arsheen M. Rajan, Masahiro Narimatsu, Andreea Obersterescu, Melanie Pye, Daniel Trcka, Kin Chan, Arshad Ayyaz, Jeffrey L. Wrana
The paper identifies revSCs as regenerative cells in damaged intestinal crypts, showing TGFβ and Hippo pathways are critical for their function and intestinal regeneration.
Nature Cell Biology · Nov 15, 2024Peer-reviewedMolecular Biology