Virginia Cecconi

Altered follicular immunity in secondary lymphoid organs is associated with interferon hyperactivity in Down syndrome

This study identifies altered follicular immunity and interferon hyperactivity in Down syndrome through single-cell and spatial profiling of human tonsils.

Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.

Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver

This study shows hepatic iNKT cells promote colorectal cancer metastasis by creating a fibrotic niche through IL-4 and IL-13 signaling.

Pre-existing intratumoral stem-like CD8+ T-cells drive radiotherapy-induced tumor control

The paper shows pre-existing stem-like CD8+ T-cells are essential for radiotherapy-induced tumor control by expanding and differentiating into effector cells.

Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

This study shows that cancer-cell-derived cGAMP both enhances and limits CD8+ T cell anti-tumor activity through STING signaling.

Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

This study identifies IFN-gamma as a dormancy inducer and IL-17A as a wake-up signal for metastatic cancer cells, showing distinct requirements for induction and awakening from dormancy.

Sustained innate interferon is an essential inducer of tertiary lymphoid structures

This study identifies sustained type I interferon signaling as essential for the development of functional tertiary lymphoid structures in the lungs during inflammation.