W. Benman

Multiplexed dynamic control of temperature to probe and observe mammalian cells.

The paper introduces thermoPlate, a device for dynamic temperature control in cell culture, and uses it to study temperature-dependent cellular responses like phase separation and stress granule dynamics.

Rapid optogenetic clustering of a cytoplasmic BcLOV4 variant

This paper engineers a BcLOV4 variant, BcLOVclust, that clusters in the cytoplasm without membrane translocation, offering faster kinetics and multiplexing capabilities compared to Cry2.

Enhancing single-cell western blotting sensitivity using diffusive analyte blotting and antibody conjugate amplification

This paper improves single-cell western blotting sensitivity using nitrocellulose blotting and enzyme-antibody conjugates, achieving a 520-fold improvement in limit of detection.

Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor

This study shows that BcLOV4 photoreceptor clusters and translocates to the plasma membrane in response to blue light, enabling new optogenetic tools for activating ErbB tyrosine kinases.