L. J. Bugaj

Rapid optogenetic clustering of a cytoplasmic BcLOV4 variant

This paper engineers a BcLOV4 variant, BcLOVclust, that clusters in the cytoplasm without membrane translocation, offering faster kinetics and multiplexing capabilities compared to Cry2.

Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor

This study shows that BcLOV4 photoreceptor clusters and translocates to the plasma membrane in response to blue light, enabling new optogenetic tools for activating ErbB tyrosine kinases.

Decoding of YAP levels and dynamics by pluripotency factors

The paper investigates how YAP activation levels and dynamics regulate pluripotency factors Oct4 and Nanog through differential thresholds and adaptive transcriptional responses.

Simple visualization of submicroscopic protein clusters with a phase-separation-based fluorescent reporter.

This paper introduces CluMPS, a fluorescent reporter that detects and amplifies submicroscopic protein clusters, enabling visualization of small oligomers and endogenous protein assemblies.

Oncogenic protein condensates suppress growth factor perception and modulate drug tolerance

This study shows that oncogenic protein condensates suppress RTK signaling and modulate drug tolerance in ALK-driven cancers by sequestering adapter proteins and enabling paracrine survival signals.

Single-component optogenetic tools for inducible RhoA GTPase signaling

The paper develops optogenetic tools to control RhoA GTPase signaling by directly recruiting effectors to the plasma membrane with light, enabling precise spatiotemporal regulation of actin organization and mechanotransduction.