Repurposing the CRISPR-Cas9 System for Targeted Chromatin O-linked β-N- acetylglucosamine Editing
M. P. Parker, W. B. Dias, W. Brautman, N. Lowe, H. Fedosyuk, K. R. Peterson, C. Slawson
This paper develops a CRISPR-Cas9-based system to manipulate O-GlcNAc modification at cis-regulatory elements, demonstrating its role in γ-globin gene regulation.
bioRxiv · Oct 27, 2022 · PreprintBiochemistry