Betulonic acid derivatives inhibiting coronavirus replication in cell culture via the nsp15 endoribonuclease
B. Krasniqi, A. Stevaert, B. Van Loy, T. Nguyen, J. Thomas, J. Vandeput, D. Jochmans, V. Thiel, R. Dijkman, W. Dehaen, A. Voet, L. Naesens
This study identifies betulonic acid derivatives as inhibitors of coronavirus replication by targeting the nsp15 endoribonuclease, with EC50 of 0.6 M against 229E.
bioRxiv · Dec 10, 2020Microbiology