Phylogenetic and protein structure analyses provide insight into the evolution and diversification of the CD36 domain 'apex' among scavenger receptor class B proteins across Eukarya
R. T. Boohar, L. E. Vandepas, N. Traylor-Knowles, W. E. Browne
The paper analyzes SR-B homologs across 165 eukaryotic species to show conserved beta barrel structure and lineage-specific sequence expansions in the CD36 apex region, suggesting evolutionary divergence in ligand sensing.
bioRxiv · Nov 13, 2023Evolutionary Biology