Reconstituting spore cortex peptidoglycan biosynthesis reveals a deacetylase that catalyzes transamidation
M. J. Tobin, S. Y. Cho, W. Profy, T. M. Ryan, D. H. Le, C. Lin, E. Z. Yip, J. L. Dorsey, B. R. Levy, J. D. Rhodes, M. A. Welsh
This study reconstitutes spore cortex peptidoglycan biosynthesis in vitro, demonstrating that CwlD and PdaA together generate muramic-δ-lactam, with PdaA acting as a transamidase.
bioRxiv · Mar 12, 2023Biochemistry