C. Lin

High resolution spatial transcriptomic and proteomic profiling of early primate gastrulation in utero

The paper provides a high-resolution spatial transcriptomic and proteomic map of early primate gastrulation, identifying key cell populations and signaling networks.

Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

The paper identifies a conserved heparan sulfate binding domain in MPXV H3 using AI and MD simulations, validates its role in viral adhesion, and demonstrates a protein inhibitor that disrupts this interaction, inhibiting infection in vitro and in vivo.

A DNA-based molecular clamp for probing protein interactions and structure under force.

The paper develops a DNA-based molecular clamp to apply tension to proteins and study their interactions and structure under force.

Predicting Primary Graft Dysfunction in Lung Transplantation: Machine Learning-Guided Biomarker Discovery

This study uses machine learning to identify cytokines predictive of primary graft dysfunction in lung transplantation, finding BAL fluid at 2h post-transplant as the strongest predictor.

Defining the heterogeneous molecular landscape of lung cancer cell responses to epigenetic inhibition

The paper profiles molecular responses to HDAC inhibitors in diverse cell lines, revealing heterogeneous protein remodeling and cell-type specific effects.

Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples

The paper develops a tagless LysoIP method to isolate lysosomes from clinical samples and human cell lines, revealing glycerophosphodiesters as potential biomarkers for lysosomal storage disorders.

Channel width modulates the permeability of DNA origami based nuclear pore mimics

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

Worldwide study of the taste of bitter medicines and their modifiers

This study examines bitterness perception of medicines and modifiers across diverse ancestries, finding ancestry-related differences in bitterness ratings and genetic associations with taste sensitivity.

Smad4 Loss in the Mouse Intestinal Epithelium Alleviates the Pathological Fibrotic Response to Injury in the Colon

This study shows that Smad4 loss in the mouse intestinal epithelium reduces pathological fibrosis and improves mucosal repair after DSS-induced injury.

Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC

This paper develops DuoMYC, a synthetic miniprotein that inhibits MYC-driven transcription by binding to E-Box DNA with high affinity and stability.

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.

This paper shows that miR-26b deficiency worsens MASH in mice, and that miR-26b mimic-loaded LNPs can reverse these effects.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow

The paper proposes lipid osmosis as a mechanism for lipid flow driven by membrane protein density and tension differences, and explores its biological functions and testing methods.

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

Thiazolidinediones are partially effective bitter blockers

This study evaluates the effectiveness of thiazolidinediones (TZDs) as bitter blockers by testing their ability to reduce bitterness of TAF and PRAZ in two taste panels.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Cbl and Cbl-b Ubiquitin Ligases are Essential for Intestinal Epithelial Stem Cell Maintenance

This study shows that Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance by regulating the Akt-mTOR pathway.

Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion

This study identifies CD44 as a co-receptor used by Plasmodium falciparum for erythrocyte invasion, showing it enhances parasite entry through cytoskeletal protein phosphorylation.

LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration

This study shows that LIFR in hepatocytes regulates neutrophil recruitment and activity to promote liver regeneration through CXCL1-CXCR2 and cholesterol-HGF pathways.

Reconstituting spore cortex peptidoglycan biosynthesis reveals a deacetylase that catalyzes transamidation

This study reconstitutes spore cortex peptidoglycan biosynthesis in vitro, demonstrating that CwlD and PdaA together generate muramic-δ-lactam, with PdaA acting as a transamidase.

Real-time spectral library matching for sample multiplexed quantitative proteomics.

This paper introduces a real-time library searching workflow to improve quantitation in sample multiplexed proteomics by enabling intelligent scan triggering and peak selection.

SGC-CAMKK2-1: A chemical probe for CAMKK2

This paper introduces SGC-CAMKK2-1, a selective chemical probe for CAMKK2, demonstrating its potential as a tool to study the therapeutic benefits of CAMKK2 inhibition.

Refined novel techniques for long term cryo-storage using vitrification and laser warming

The paper develops a customized cryo-jig for improved laser striking accuracy and rewarming success in long-term cryo-storage using vitrification and laser warming.

Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins

This study shows that deleting CerS6 reduces alcohol-induced fatty liver and improves glucose homeostasis in mice, and links CerS6 expression to ALD progression in humans.

Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo (Phyllostachys edulis)

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

Locating cellular contents during cryoFIB milling by cellular secondary-electron imaging

This paper introduces a method to locate cellular contents during cryoFIB milling using secondary-electron imaging, demonstrating its feasibility across different instruments and conditions.

Neuroanatomy of stomatopod central complexes offers putative neural substrate for oriented behaviors in crustaceans

This study examines the neuroanatomy of the central complex in mantis shrimps to understand its role in orientation and navigation in a marine crustacean.

State-dependent protein-protein interactions mediating 4-1BB CAR Signaling

The paper identifies a network of protein interactions activated by 4-1BB CARs upon target engagement and shows that network activation magnitude correlates with IL-2 secretion.

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence

This paper designs a small molecule STING agonist, SNX281, using computational methods and AI, showing systemic activity and antitumor effects in mice.

CLASP2 stabilizes GDP-associated terminal tubulins to prevent microtubule catastrophe

This study identifies CLASP2's mechanism of stabilizing GDP-associated terminal tubulins to prevent microtubule catastrophe.