The formation of intramolecular secondary structure brings mRNA ends in close proximity
W.-J. C. Lai, M. Kayedkhordeh, E. V. Cornell, E. Farah, S. Bellaousov, R. Rietmeijer, D. H. Mathews, D. N. Ermolenko
The paper shows that mRNAs from various organisms, including humans, inherently fold into structures bringing their ends within 7 nm, regardless of length, except for specific unstructured sequences.
bioRxiv · Mar 27, 2018Biochemistry