TGF-β Mediated Cell Adhesion Dynamics and Epithelial to Mesenchymal Transition in 3D and 2D Ovarian Cancer Models
Wafa Al Ameri, Ikhlak Ahmed, Fatima M. Al-Dasim, Yasmin Ali Mohamoud, Iman K. AlAzwani, Joel A. Malek, Thasni Karedath
This study compares 3D and 2D ovarian cancer models to show TGF-β induces EMT, invasion, and aggressiveness, with reversible effects using a TGF-β inhibitor.
bioRxiv · Nov 8, 2018 · PreprintCancer Biology