GYS2 Promotes the Progression of Aortic Dissection and Aortic Aneurysm via C5a/NF-κB-Mediated Pro-Inflammatory Macrophage Polarization
lei jin, Liya Ma, Juncheng Liu, Zongsheng Jiang, Wangting Wu, Ying Liu, Anqi Xie, Xueping Huang, Xinmeng Xie, Liangwan Chen, L P Zhang, Zhihuang Qiu
This study shows that GYS2 promotes aortic dissection and aneurysm by driving pro-inflammatory macrophage polarization through the C5a/NF-κB pathway.
bioRxiv · Jun 12, 2026 · PreprintMolecular Biology