Smoothened turnover regulated by Hedgehog signaling in Drosophila
Ryo Hatori, Wanpeng Wang, Thomas B. Kornberg
The paper investigates protein turnover and intracellular trafficking of Hedgehog signaling components in Drosophila wing discs and finds that Smoothened's distribution and half-life are regulated by Hedgehog signaling.
bioRxiv · Jan 9, 2026 · PreprintDevelopmental Biology