SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth
Mengyao Qin, Li Shi, Hao Chen, Chan Liu, Zhiquan Tang, Donghao An, Wanting Yu, Dandan He, Chang Shao, Hong Yu, Hong Yu, Haiping Hao, Jing Xiong
This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.
Science Advances · Apr 8, 2026Peer-reviewedCancer Biology