Wanying Sun

Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients

This study characterizes intra-host SARS-CoV-2 genomic variants and their evolutionary dynamics in COVID-19 patients using deep sequencing data.

Population Bottlenecks and Intra-host Evolution during Human-to-Human Transmission of SARS-CoV-2Population Bottlenecks and Intra-host Evolution during Human-to-Human Transmission of SARS-CoV-2

This study compares SARS-CoV-2 viral populations in COVID-19 patients to show narrow transmission bottlenecks and stochastic dynamics in intra-host and inter-host evolution.

A path towards SARS-CoV-2 attenuation: metabolic pressure on CTP synthesis rules the virus evolution

The paper identifies CTP synthesis as a metabolic bottleneck that constrains SARS-CoV-2 evolution towards attenuation and highlights viperin's role in antiviral defense.

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

This paper compares amplicon, hybrid capture, and metatranscriptomic sequencing methods for directly sequencing SARS-CoV-2 genomes from clinical samples, finding differences in bias, sensitivity, and accuracy.

Recovered and dead outcome patients caused by influenza A (H7N9) virus infection show different pro-inflammatory cytokine dynamics during disease progress and its application in real-time prognosis

This study analyzes cytokine dynamics in H7N9-infected patients with different outcomes, identifying predictors and a real-time prognosis model.