GM1 and GD3 Gangliosides Attenuate NGF-TrkA and BDNF-TrkB Signaling Dysfunction Associated with Acute Diisopropylfluorophosphate Exposure in Mouse Brain
Yutaka Itokazu, Wayne D. Beck, Alvin V. Terry
This paper shows that intranasal gangliosides GM1 and GD3 prevent organophosphate-induced neurotrophin signaling dysfunction in mice, protecting against cognitive and depressive symptoms.
bioRxiv · Mar 31, 2025 · PreprintPharmacology & Toxicology