Author

Weiping Lyu

Capital Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Bin XiiD· 1 shared Bo HuangiD· 1 shared Cheng ShiiD· 1 shared Dehua LuiD· 1 shared Haixian ZhangiD· 1 shared Han WangiD· 1 shared Qi Li· 1 shared Siyu XiuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Bin XiORCID

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1 paper

Recent·Most cited

A closed-loop reinforcement learning framework for rapid compound directed optimization

Han Wang, Dehua Lu, Weiping Lyu, Siyu Xiu, Cheng Shi, Xiaonan Zhou, Bin Xi, Wei Feng, Yang Xiao, Yanming Chen, Haixian Zhang, Qi Li, Bo Huang, Zhenming Liu

This paper introduces RCDO, a closed-loop reinforcement learning framework that accelerates compound optimization by integrating experimental feedback with generative models, achieving significant improvements in drug candidate properties.

bioRxiv · Aug 27, 2026 · PreprintBioinformatics