BioinformaticsbioRxivPreprint
A closed-loop reinforcement learning framework for rapid compound directed optimization
Han Wang, Dehua Lu, Weiping Lyu…·Zhenming Liu
This paper introduces RCDO, a closed-loop reinforcement learning framework that accelerates compound optimization by integrating experimental feedback with generative models, achieving significant improvements in drug candidate properties.
DOI 10.64898/2026.08.24.745890