p300/CBP-Driven Acetylation Stabilizes PARP7 to Reinforce Negative Feedback on IFN-I Signaling
Dan Li, Yao Liu, Ying Wang, Weijie Liu, Shihui Zhu, Ying Zhang, Luyi Wang, Xiaoqin Zhou, Wen Ding, Sanyong Zhu, Yongjun Dang, Jianmin Wu
This study identifies p300/CBP-mediated acetylation of PARP7 as a mechanism to suppress IFN-I signaling in tumor cells, with implications for enhancing antitumor immunity.
bioRxiv · Jan 30, 2026 · PreprintCancer Biology