Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelination
Félix Distéfano‐Gagné, Nesrine Belhamiti, William Saxon, Sara Bitarafan, André Machado Xavier, Stéphanie Fiola, Serge Rivest, David Gosselin
The paper identifies two functionally distinct inflammatory microglial states in mice associated with demyelination and shows how signaling and epigenomic mechanisms drive their transcriptional reprogramming.
bioRxiv · Aug 21, 2025 · PreprintNeuroscience