Dietary fiber-type-specific gut microbiome preconditioning drives differential susceptibility to sporadic colon cancer development
Sangshan Tian, Sumudu Rajakaruna, Gopi Yalavarthi, Umesh Kumar Goand, Tinghua Chen, Won Gu, Justin Silverman, Fuhua Hao, Seth R. Bordenstein, Jordan E. Bisanz, Amit Kumar Tiwari, Andrew D Patterson, Vishal Singh
The paper shows that inulin supplementation increases colon tumor incidence in mice by altering gut microbiome and metabolome, creating a tumor-promoting environment when exposed to carcinogens.
bioRxiv · Oct 22, 2026 · PreprintMicrobiology