Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity
Koichiro Haruwaka, Juan Liu, Yue Liang, Shinya Matsumoto, Dimitrios Kleidonas, Wu Shi, Shunyi Zhao, Yong Liu, Anthony D. Umpierre, Zhongcong Xie, Miao Jing, Long‐Jun Wu
The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.
bioRxiv · Jul 6, 2026 · PreprintNeuroscience