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Gut Virome Diversity and Health Status in Rescued Pangolins: Metaviromics Reveals Parvovirus as a Key Virus Associated with Disease

This study characterizes the gut virome of pangolins across health states, finding a shift from phage-dominated to eukaryotic virus-dominated viromes in diseased individuals, with Parvoviridae and Iridoviridae as potential pathogens.

Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis

This study shows that inhibiting folate-dependent purine synthesis in melanoma cells enhances their sensitivity to T cell killing by suppressing glycolysis and reducing PD-L1 stability.