Cancer BiologybioRxivPreprint
Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis
D J Li, Miaomiao Hou, Shoubao Wang…·X Hu
This study shows that inhibiting folate-dependent purine synthesis in melanoma cells enhances their sensitivity to T cell killing by suppressing glycolysis and reducing PD-L1 stability.
DOI 10.64898/2026.07.06.736685