Breast cancer interactions with osteoclasts generate osteoclast tumor hybrid like cells through dynamic non-canonical cell fusion and cell-in-cell processes
King Hoo Lim, Damrongrat Siriwanna, XS Li, Eunice Dotse, Meijun Wang, Choa Mun, Yusong Li, X L Wang, Kwan Ting Chow
The paper shows breast cancer cells interact with osteoclasts to form hybrid-like cells via cell fusion and cell-in-cell processes, altering ECM and immunoregulatory pathways.
bioRxiv · Apr 7, 2026 · PreprintCancer Biology