An opioid efficacy switch for reversible optical control of peripheral analgesia
Luca Posa, Giovanna R. Romano, Xiang Ji, Saif Ahmad Khan, Bruno Matos Paz, Gye Won Han, Antonina L. Nazarova, Saheem A. Zaidi, Vsevolod Katritch, Cornelius Gati, Dirk H. Trauner, Joshua Levitz
This paper introduces a photoswitchable opioid agonist that enables optical control of peripheral analgesia with reduced side effects.
Journal of Pain · Apr 1, 2025Peer-reviewedPharmacology & Toxicology