Author

Xiang Lei

Shenzhen Bay Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alessandra GiorgettiiD· 1 shared Damià Romero–MoyaiD· 1 shared Ehsan HashemiiD· 1 shared Jiaxuan LiiD· 1 shared Joe Z. ZhangiD· 1 shared Keke Sun· 1 shared Qingwei Zeng· 1 shared Qingyan Wu· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Alessandra GiorgettiORCID

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2 papers

Recent·Most cited

TRU-PE: A Universal, Trackable Prime Editor Toolkit for Robust Single- and Multi-Locus Genome Engineering

Zhichao Qiu, Keke Sun, Qingwei Zeng, Ziwei Luo, Xinran Liu, Yaping Li, Xiang Lei, Ruilin Zhao, Zhen Zhang, Damià Romero–Moya, Yuan Yang, Xuan Wang, Ehsan Hashemi, Joe Z. Zhang, Xiaolong Wang, , Zhuobin Liang

TRU-PE improves prime editing efficiency and scalability for genome engineering in human cells, enabling multi-locus edits and a platform for studying genetic disorders.

bioRxiv · Feb 21, 2026 · PreprintGenetics

Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing

Tianzi Wei, Jiaxuan Li, Xiang Lei, Risheng Lin, Qingyan Wu, Zhenfeng Zhang, Shimin Shuai, Ruilin Tian

This study identifies DDX39B as a global repressor of A-to-I RNA editing using CRISPR screens and shows its potential as a therapeutic target for anti-HDV therapy.

Cell Reports · Jul 1, 2025Peer-reviewedMolecular Biology