Time-Resolved Profiling: Metabolic Adaptation & Morphology-Specific Drug Response in MCF-7 spheroids
Annamarija Raić, Marcel Utz, Sylwia Barker, Nora Schäfer, Yaping Li
This study compares metabolic and phenotypic responses of MCF-7 cells in 2D and 3D cultures to 5-FU, finding that 3D architecture drives metabolic changes and reduced drug sensitivity.
bioRxiv · Jul 26, 2026 · PreprintCancer Biology