Near completely reversing the γ- to β-globin switch by enhancer release, retargeting and reinforcing
Nanyu Wang, Ke Yang, Xuemin Xie, Shenshen Cui, Xiaoya Pei, Xiang Zhao, Delong Hao, Yuyan Jia, Gaohui Yang, Rongrong Liu, Ping Chen, Wenji Dong, Yue Huang, Xiang Lv, Zhuqin Zhang, Depei Liu
This study demonstrates that combined editing of CACCC and TGACCA motifs can nearly reverse the γ- to β-globin switch by redirecting enhancer-promoter interactions.
bioRxiv · Feb 1, 2026 · PreprintMolecular Biology