Multi-Domain Interplay Controls Full-Length TDP-43 Phase Separation and Condensate Dynamics
Xiaofei Ping, Rodrique G. M. Badr, Saskia Hutten, Xinxiang Chen, Lucia Baltz, Mahesh Yadav, Jana Sophie Höppner, Friederike Schmid, Dorothee Dormann, Lukas S. Stelzl
This study shows how different domains of TDP-43 interact to control phase separation and condensate dynamics through simulations and experiments.
bioRxiv · Oct 7, 2026 · PreprintBiophysics