A Humanized IFN-γ Mouse Model Reveals Skin Eschar Formation, Enhanced Susceptibility and Scrub Typhus Pathogenesis
Ryan Cho, Lihai Gao, Hui Wang, Yixuan Zhou, Casey Gonzales, Dario Villacreses, Emmett A. Dews, Xiaofei Zhou, Ruili Lv, Hema Prasad Narra, Lynn Soong, Yuejin Liang
This study develops a humanized IFN-γ mouse model that shows increased susceptibility to Orientia tsutsugamushi infection, skin eschar formation, and immune dysregulation, mimicking human scrub typhus pathogenesis.
PLoS Pathogens · Feb 11, 2026Peer-reviewedImmunology