A Vma13-targeted thiadiazole-succinimide disrupts V-ATPase dependent arginine-polyamine homeostasis to block Candida albicans escape from macrophages
Xinyu Fang, Bingchen Jiang, Wanqian Li, Xiaojing Xu, Liping Xu, Xiao Zhou, Wenqing Shi, Yuanying Jiang, Hui Lu
This paper identifies a small molecule that disrupts C. albicans' ability to escape macrophages by targeting Vma13/V-ATPase and disrupting arginine-polyamine homeostasis.
bioRxiv · Nov 2, 2026 · PreprintMicrobiology