A tRNA-derived small RNA orchestrates cardioprotection through distinct cell-type-specific mechanisms
Tian Hao, Jin Li, Kaushik V Amancherla, Lingfei Sun, Priyanka Gokulnath, Alejandra Patino-Guerrero, Ritin Sharma, Krystine Garcia‐Mansfield, Chunyang Xiao, Aidan C. Manning, Emeli Chartterjee, Xiaoting Yu, Richard Xu, Yiming Zhang, Zhihong Yang, , Guoping Li
This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.
bioRxiv · Sep 29, 2026 · PreprintCell Biology