Author

Xiaowen Hao

Center for Life Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Xiaohua SheniD· 2 shared Yantao Hong· 2 shared Dingfei Yan· 1 shared Haiteng DengiD· 1 shared Jie NaiD· 1 shared Jing ZhangiD· 1 shared Jingzhao Xu· 1 shared Linqing XingiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Xiaohua ShenORCID

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2 papers

Recent·Most cited

Translation sustains productive Pol II elongation through maintenance of nuclear RNA surveillance

Mengyuan Huang, Yantao Hong, Ruiqi Deng, Yilin Liu, Yi Zhou, Xiaowen Hao, Zheng Zheng, Linqing Xing, Xiaohua Shen

This study shows that ongoing translation sustains productive Pol II elongation and nuclear RNA homeostasis in mouse embryonic stem cells by maintaining RNA surveillance.

bioRxiv · Jun 23, 2026 · PreprintMolecular Biology

Co-transcriptional RNA processing boosts zygotic gene activation

Jingzhao Xu, Xiaojing Li, Xiaowen Hao, Xinyun Hu, Shaoqian Ma, Yantao Hong, Jing Zhang, Dingfei Yan, Haiteng Deng, Jie Na, Xiong Ji, Zai Chang, Xiaohua Shen

This study shows that co-transcriptional RNA processing via the CTD of Pol II is essential for zygotic gene activation, as disrupting it halts mRNA synthesis and increases noncoding RNA levels.

bioRxiv · Sep 14, 2024 · PreprintDevelopmental Biology