Enhancer-priming in ageing human bone marrow mesenchymal stromal cells contributes to immune traits
Mang Ching Lai, Mariana Ruiz-Velasco, Christian Arnold, Olga M. Sigalova, Daria Bunina, Ivan Berest, Ximing Ding, Marco L. Hennrich, Laura Poisa-Beiro, Annique Claringbould, Anna Mathioudaki, Caroline Pabst, Anthony Dick Ho, Anne‐Claude Gavin, Judith B. Zaugg
This study uses multiomics analysis of BMSCs to show age-related changes in enhancer activity and gene regulation contribute to immune traits and tissue-specific disorders.
bioRxiv · Sep 3, 2021 · PreprintSystems Biology