Author

Xinrui Chen

MGI

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Andrew W. CarrolliD· 1 shared Bing LiuiD· 1 shared Haolong Zhou· 1 shared Heng YiiD· 1 shared Hongliang WangiD· 1 shared Huan CheniD· 1 shared Kishwar ShafiniD· 1 shared Lingyun XuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Andrew W. CarrollORCID

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2 papers

Recent·Most cited

PanVariants: Best Practice for Pangenome-based Variant Calling Pipeline and Framework

Heng Yi, Linqi Wang, Xinrui Chen, Yi Ding, Andrew W. Carroll, Pi-Chuan Chang, Kishwar Shafin, Lingyun Xu, Xiaojie Zeng, Xia Zhao, Meihua Gong, Xiaofang Wei, Yong Hou, Ming Ni

PanVariants improves variant calling by integrating k-mer and mapping methods, reducing errors and outperforming existing tools for SNVs, indels, and SVs.

bioRxiv · May 17, 2026 · PreprintBioinformatics

MsyB-HU Interaction Modulates a Two-Tiered Bacterial Stress Response by Regulating DNA Supercoiling

Huan Chen, Yanan Yang, Xinrui Chen, Haolong Zhou, Yingli He, Mengzhe Li, Wei Lin, Zuyi Yuan, Yawen Wang, Stephen Matthews, Shuai Yuan, Hongliang Wang, Bing Liu

This study identifies MsyB as a HU inhibitor and β-clamp binder in E. coli, showing it modulates DNA supercoiling to influence transcription and adaptive mutation under stress.

bioRxiv · Feb 25, 2025 · PreprintMicrobiology