Wei Lin

Tipping Points and Emergent Phases of Species Diversity in Mutualistic Ecological Networks under Global Warming

This study identifies climate-induced tipping points in mutualistic ecological networks under global warming, showing three phases of species diversity and the impact of warming rate on ecosystem resilience.

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids

This study uses human iPSC-derived cortical organoids to model familial Alzheimer's disease and shows that autophagy activators reduce pathological Tau and Aβ accumulation and rescue synaptic loss.

FEDRANN: effective long-read overlap detection based on dimensionality reduction and approximate nearest neighbors

FEDRANN improves long-read overlap detection using dimensionality reduction and approximate nearest neighbors, outperforming existing methods on real data.

A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function

This study identifies the SUMO-interacting motif in EPAC1 as critical for its subcellular targeting and functional regulation, including cAMP binding and signaling microdomain formation.

MsyB-HU Interaction Modulates a Two-Tiered Bacterial Stress Response by Regulating DNA Supercoiling

This study identifies MsyB as a HU inhibitor and β-clamp binder in E. coli, showing it modulates DNA supercoiling to influence transcription and adaptive mutation under stress.

Structural basis of translation in transcription-translation coupling

The paper reports cryo-EM structures of transcription-translation complexes (TTCs) at different stages of the translation cycle in E. coli, revealing structural changes and their functional implications.

Mining bacterial NGS data vastly expands the complete genomes of temperate phages

This study expands the number of complete temperate phage genomes by over 100-fold using a novel computational method applied to bacterial NGS data.

Establishment of a hypoxia ischemia reperfusion brain damagemodel in neonatal rats

This study establishes a new neonatal rat model for hypoxia ischemia reperfusion brain damage by using a CCA muscle bridge method, showing effective ischemia reperfusion and brain damage.

Detection of Deformed wing virus (DWV) in the Vietnamese Walking Stick Medauroidea extradentata (Phasmatodea)

The paper detects Deformed wing virus (DWV) in the Vietnamese Walking Stick Medauroidea extradentata using RNAseq data and constructs its complete genome sequence.

The origin of the odorant receptor gene family in insects

The paper investigates the origin of the odorant receptor (OR) gene family in insects, finding that ORs evolved with an ancestral co-receptor (Orco) in the ancestor of all insects, supporting a terrestrial lifestyle adaptation rather than winged flight.

The draft genome of the invasive walking stick, Medauroidea extradendata, reveals extensive lineage-specific gene family expansions of cell wall degrading enzymes in Phasmatodea

The paper reports the genome of Medauroidea extradentata, revealing lineage-specific expansions of pectinase gene families in Phasmatodea.

Sphinx: modeling transcriptional heterogeneity in single-cell RNA-Seq

The paper introduces a model to detect changes in transcriptional heterogeneity using burst proportion and magnitude, validated by RNA-FISH.