An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts
Yuxin Guo, Sicheng Shu, Yong Zhou, Wenjing Peng, Zhimin Jiang, Yudong Li, Tian Li, Fanshu Du, Linlin Wang, Xue Chen, Jinze Dong, Chuankuo Zhao, Maggie Haitian Wang, Yipeng Sun, Honglei Sun, , Juan Pu
This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.
Journal of Virology · Aug 27, 2025Peer-reviewedMicrobiology