Retinal Phd2 ablation partially rescues Crb1Crb2-associated Leber congenital amaurosis and alters metabolic signaling
Vaishnavi Karthikeyan, Charlotte A. Andriessen, Anne Peeters, Xuefei Lu, Aat A Mulder, Zohreh Hosseinzadeh, Roman I. Koning, Jan Wijnholds
This study shows that deleting Phd2 in Crb1/Crb2-deficient mice partially improves retinal function and structure but does not correct underlying defects.
bioRxiv · Oct 29, 2026 · PreprintNeuroscience