Cancer BiologybioRxiv
Molecular basis for substrate recruitment to the PRMT5 methylosome
K. M. Mulvaney, C. Blomquist, N. Acharya…·W. R. Sellers
The paper identifies a conserved peptide sequence in PRMT5 substrate adaptors that mediates their interaction with PRMT5 and shows its necessity for methylation of substrates like spliceosome, histones, and ribosome complexes.
DOI 10.1016/j.molcel.2021.07.019