Author

D. Porter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

A. Ianari· 2 shared A. Skepner· 2 shared D. C. McKinney· 2 shared K. M. Mulvaney· 2 shared M. Ranaghan· 2 shared W. R. Sellers· 2 shared A. Garrett· 1 shared A. Hope· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Ianari

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Application of an NMR/crystallography fragment screening platform for the assessment and rapid discovery of new HIV-CA binding fragments

S. Lang, D. A. Fletcher, A.-P. Petit, N. Luise, P. K. Fyfe, F. Zuccotto, D. Porter, A. Hope, F. Bellany, C. Kerr, C. J. MacKenzie, P. G. Wyatt, D. W. Gray

The paper uses NMR and crystallography to identify and assess new HIV-CA binding fragments, leading to the discovery of two compounds with improved binding properties.

bioRxiv · Dec 1, 2023Pharmacology & Toxicology

The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance.

N. R. De Lay, N. Verma, D. Sinha, A. Garrett, M. K. Osterberg, S. Reiling, D. Porter, D. P. Giedroc, M. E. Winkler

This paper identifies five CiaR-controlled Ccn sRNAs in S. pneumoniae that modulate Zn resistance and virulence by regulating metal homeostasis and detoxification mechanisms.

bioRxiv · Nov 7, 2023 · PreprintMicrobiology

Discovery of a first-in-class inhibitor of the PRMT5-substrate adaptor interaction

D. C. McKinney, B. J. McMillan, M. Ranaghan, J. A. Moroco, M. Brousseau, Z. Mullin-Bernstein, M. O'Keefe, P. McCarren, M. F. Mesleh, K. M. Mulvaney, R. Singh, B. Bajrami, A. Skepner, D. E. Timm, D. Porter, , A. Ianari

The paper identifies a first-in-class inhibitor, BRD0639, that targets the PRMT5-PBM interaction, disrupting SAP binding and reducing substrate methylation in cancer cells.

bioRxiv · Feb 3, 2021 · PreprintCancer Biology

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

D. Martinez, A. Schaefer, S. R. Leist, D. Li, K. Gully, J. Feng, E. Bunyan, D. Porter, T. Cihlar, S. Montgomery, B. Haynes, R. S. Baric, M. C. Nussenzweig, T. P. Sheahan

This study evaluates combination therapies of remdesivir and monoclonal antibodies for SARS-CoV-2 and its B.1.351 variant in mice, showing improved outcomes with the antibody combination.

bioRxiv · Jan 27, 2021Microbiology

Molecular basis for substrate recruitment to the PRMT5 methylosome

K. M. Mulvaney, C. Blomquist, N. Acharya, R. Li, M. OKeefe, M. Ranaghan, M. Stokes, A. J. Nelson, S. S. Jain, J. Columbus, F. K. Bozal, A. Skepner, D. Raymond, D. C. McKinney, Y. Freyzon, , W. R. Sellers

The paper identifies a conserved peptide sequence in PRMT5 substrate adaptors that mediates their interaction with PRMT5 and shows its necessity for methylation of substrates like spliceosome, histones, and ribosome complexes.

bioRxiv · Aug 22, 2020Cancer Biology

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

B. Williamson, F. Feldmann, B. Schwarz, K. Meade-White, D. Porter, J. Schulz, N. van Doremalen, I. Leighton, C. K. Yinda, L. Perez-Perez, A. Okumura, J. Lovaglio, P. Hanley, G. Saturday, C. Bosio, , E. de Wit

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

bioRxiv · Apr 15, 2020Microbiology

Environmental reservoirs of Mycobacterium bovis and Mycobacterium tuberculosis in the Ruaha region, Tanzania

E. R. Travis, Y. Hung, D. Porter, G. Paul, R. James, A. Roug, M. Kato-Maeda, R. Kazwala, W. A. Smith, P. Hopewell, O. Courtenay, E. M. Wellington

This study detects Mycobacterium bovis and Mycobacterium tuberculosis in environmental samples from Tanzania, finding seasonal and geographical variations and suggesting cross-species transmission.

bioRxiv · Oct 2, 2019 · PreprintMicrobiology